Short Communication Morbid Obesity Alters both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction
نویسندگان
چکیده
Ocular Surface Research Center and Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China (D.D.); Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou, China (X.P., J.L.); Department of Pharmacy, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (J.L.); and Division of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou, China (H.Q., B.W.) This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on August 1, 2016 as DOI: 10.1124/dmd.116.071605
منابع مشابه
Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction.
The prevalence of obesity has markedly increased worldwide. Obese patients pose significant challenges to anesthesiologists with regard to accurate dosing of anesthetics due to potentially altered pharmacokinetics (PK). Here we determined the PK and pharmacodynamics (PD) of propofol for anesthesia induction in morbidly obese (MO) subjects (body mass index >35 kg/m(2)) at two dosing regimens: do...
متن کاملEvaluation of propofol anesthesia in morbidly obese children and adolescents
BACKGROUND Poor characterization of propofol pharmacokinetics and pharmacodynamics in the morbidly obese (MO) pediatric population poses dosing challenges. This study was conducted to evaluate propofol total intravenous anesthesia (TIVA) in this population. METHODS After IRB approval, a prospective study was conducted in 20 MO children and adolescents undergoing laparoscopic surgery under cli...
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Available propofol pharmacokinetic protocols for target-controlled infusion (TCI) were obtained from healthy individuals. However, the disposition as well as the response to a given drug may be altered in clinical conditions. The aim of the study was to examine population pharmacokinetics (PK) and pharmacodynamics (PD) of propofol during total intravenous anesthesia (propofol/fentanyl) monitore...
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Propofol (2,6-diisopropylphenol) is administered intravenously for induction and maintenance of anesthesia; however, cases of progressive myocardial failure (propofol syndrome) related to the use of propofol have been reported. In the present study, the individual differences in pharmacokinetics and/or pharmacodynamics of propofol were investigated in patients who were genotyped for CYP2B6 and ...
متن کاملComparison of hemodynamic changes of Propofol and Thiopental during
Introduction: General anesthesia is the most common technique for performance of various surgical procedures. Thiopental is the most common anesthetic agent for intravenous induction. Since the introduction of propofol as an anesthetic agent, its use has increased progressively and has become the drug of choice for induction of anesthesia in several conditions. The aims of this study were com...
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تاریخ انتشار 2016